Affinity Photo makes use of a highly customizable projection grid, perfect for UI/game design, digital design modelers, and mock ups.
Plane sets can be enabled so you can design on front, side and top planes; each plane can be toggled into by using a single key modifier.
Instead of the commonly used isometric projection grid, a choice of other project grid presets can be selected (e.g., dimetric, triangular); you can even create custom projection grids with options for grid sizing, custom aspect ratios, and gutters for more advanced use.
Once in a specific mode and plane set you can create line and shape drawing using the Pen Tool or pre-designed geometric shapes.
For pen drawing, use the Pen Tool's Polygon or Line Modes for straight line segments. For geometric shapes, skew shapes to fit your grid.
Grids work best when combined with snapping (switch on via top toolbar), in particular when the Snap to Grid option is enabled from the Snapping button's pop-up menu. Object handles snap precisely to any grid line and line intersections.
Grids can be based on any document unit, shown when switching on the rulers.
If you're looking beyond the projection mode presets such as isometric you can customize the grid to your liking.
You can then cycle between planes on demand to design on top, side, and front of your drawing.